Sometimes love has an expiration date, and when this happens, there's nothing you can do about it. As hard as it may be, and as much as it may hurt, you need to learn to let the people go that are now just part of your past -you have to let them fly free.
In the end, if someone has been in your life for a while, and then they leave, this is because you've learned everything that you needed to from them. The important part is that you act like rational adults and make things as easy and painless as possible.
If you're the one that decides to break things off, you need to understand that the other party will be hurt deeply and that you're the one that needs to adapt to their needs and desires. Help them to realize that even though you're no longer together, you'll always care for them and that you'll still be there for them. If you're sincere, they'll have no reason to be angry with you.
If they dumped you, don't forget that honesty is much better than this person staying with you forcibly. Although your situation is the hardest, try to remember all of the great things that you learned and experienced together and get ready for the next adventure, which will undoubtedly be even more exciting.
If you run and manage your own business, the time has come to think like a real tycoon. Banish all of your feelings and pain, and use your rational side to make decisions that will favor your economy. This doesn't mean that you have to be the bad guy, but you do need to take on every problem as need be.
Your immune system will be compromised, and you'll be prone to getting a urinary tract infection. Avoid sitting on cold surfaces, or help your body out with a cranberry supplement that could be the perfect solution to prevent this uncomfortable issue.